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The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and gabrs/gaba a receptors in rat glaucoma models. The decline in neurosteroid levels and diminished neuroprotective capacity during aging may contribute to neurodegenerative processes, leading to increased apoptosis, neuronal cell loss, and decreased proliferation and differentiation of neural precursors [43]. Neurosteroids have a crucial role in neuroprotection, benefiting both the central and peripheral nervous systems

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Notably, the neurosteroid precursor preg has the ability to significantly mitigate the detrimental consequences of glutamate toxicity [108]. Therapeutic approaches aimed at neurosteroids are likely to yield beneficial effects Neurosteroid therapy produces positive effects in experimental animal models or humans without causing harmful side effects

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However, the effects of synthetic neurosteroids are not always apparent in clinical.

Allopregnanolone, a major endogenous inhibitory neurosteroid Neurosteroids are natural and synthetic steroids that are active on the mammalian nervous system through receptors other than steroid hormone receptors It includes inhibitory, excitatory, and neurotrophic neurosteroids as well as pheromones and vomeropherines In contrast to steroid hormones, neurosteroids have.

Neurosteroids play a key role in regulation of seizure susceptibility, anxiety, and other neuropsychiatric conditions.